Synthesis of N -substituted aryl amidines by strong base activation of amines
نویسندگان
چکیده
منابع مشابه
Synthesis of N-substituted aryl amidines by strong base activation of amines.
We describe an efficient method for the direct preparation of N-substituted aryl amidines from nitriles and primary amines. The protocol employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant functional group. This synthetic approach tolerates deactivated nitriles, nitriles with competing substitution sites, and aryl amines.
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2015
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2015.05.029